New research from Harvard T.H. Chan School of Public Health suggests that manipulating mitochondrial networks inside cells — either by fasting or by a genetic manipulation that mimics dietary restriction — may improve health and increase lifespan. The study titled “Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling” was published online in Cell Metabolism.
The findings shed light on the cells’ declining ability to process energy over time, which leads to aging and age-related diseases. It also investigates how interventions, such as periods of fasting, might promote healthy aging.
The scientists used C. elegans (nematode worms), which live just two weeks, for their lab experiments.
The researchers found that restricting the worms’ diet — or mimicking dietary restriction through genetic manipulation of an energy-sensing protein called AMP-activated protein kinase (AMPK) — kept the mitochondrial networks in a “youthful” state. They also found that the youthful networks increased the worms’ lifespan by communicating with organelles called peroxisomes to modulate fat metabolism.
The research supports previous studies that suggest intermittent fasting and other ways of dietary restriction can aid in healthier aging.
Heather Weir, lead author of the study, told the Harvard Gazette:
“Low-energy conditions such as dietary restriction and intermittent fasting have previously been shown to promote healthy aging. Understanding why this is the case is a crucial step toward being able to harness the benefits therapeutically. Our findings open up new avenues in the search for therapeutic strategies that will reduce our likelihood of developing age-related diseases as we get older.”
The next step for the researchers is to test the role mitochondrial networks have in the effect of fasting in mammals.
William Mair, associate professor of genetics and complex diseases at Harvard Chan School and senior author of the study, said:
“Although previous work has shown how intermittent fasting can slow aging, we are only beginning to understand the underlying biology. Our work shows how crucial the plasticity of mitochondria networks is for the benefits of fasting. If we lock mitochondria in one state, we completely block the effects of fasting or dietary restriction on longevity.”
Do you practice intermittent fasting, and has it helped you age healthier? Let us know in the comments below!
Astronomers Just Spotted First ‘Mystery Visitor’ From Another Solar System
“We have been waiting for this day for decades,” NASA said. “So far, everything indicates this is likely an interstellar object.”
Just recently, astronomers from all over the globe have been baffled with a new discovery – a mysterious unidentified object has been found passing through our solar system. It remains unclear whether the said object, which has been described by many as “small and fast-moving,” is an asteroid or a comet.
NASA, however, has confirmed that they do not have any idea of its origins and that it isn’t behaving like other local space rocks. So it’s highly likely that it is NOT from our own solar system? Many are inclined to believe so.
Once confirmed, NASA said this discovery would mark “the first interstellar object to be observed and confirmed by astronomers."
A Robot Could Detect Cancer In Less Than A Second, Study Found
If this could become a diagnostic test, it could save millions of lives.
Today, one of the most dreaded diseases across the globe is cancer. Over the past decades, the cases of cancer in people of all ages have soared high, killing millions of individuals. The problem is, detecting cancer is difficult, especially since potent diagnostic tests are still not available.
Now, a new research suggests that artificial intelligence (AI) could detect cancer in less than a second, particularly colorectal cancer.
An artificial intelligence program could detect cancer under a second.
Science Claim Your Partner’s Fart Can Make You Live Longer
You would probably stop covering your nose once you learn how you can live longer by smelling farts.
Are you willing to smell the fart of your partner for the rest of your life? It’s gross, but will you do it if experts say you can live a lot longer by smelling your partner’s stinky gas?
Scientists just released a claim that smelling your partner’s farts will amazingly make you live longer. The research team from the University of Exeter just discovered that it is good for you to inhale your partner’s farts as these gases they release can – surprisingly – combat diseases. Sounds like a scam but it might be true.
Scientists found a very natural way of prolonging life.
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