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Rare Genetic Mutation Causes Entire Family To Feel No Pain

Members of this Italian family can suffer burns and broken bones without noticing.






An Italian family is gaining attention worldwide, thanks to a very rare and unique syndrome. Basically, six of the members of the Marsili family feel almost no pain. They are namely, Maria Domenico (the 78-year-old head of the family), her two daughters, Maria and Letizia, and their children Bernardo, Ludovico, and Virginia.

Letizia claims to have noticed the extremely low pain threshold during her childhood. Hence she was called “superwoman” by her colleagues back then. Some of the members, particularly Maria, of the Marsili family also experienced breaking a bone or two without even realizing it.

The Marsili family has a very rare genetic mutation, enabling them to feel almost no pain.

During a winter vacation, Letizia accidentally sprained her ankle. Surprisingly, she was able to walk without any issues, though the leg remained swollen for two weeks. Her son Bernardo, on the other hand, fell off a bicycle and broke his arm but did not even realize it. The trauma was only discovered after the bone started to grow back together.

Letizia’s sister, Maria, burned herself with hot drinks for a couple of times already. But just like the aforementioned family members, she did not feel any pain. Lastly, Virginia got her hand frostbitten but only managed to notice it a few days later.

They said that, in one some ways, they feel pain. The only catch is that it does not last long enough for them to notice it.

One of them sprained her ankle but was still able to walk without any problems.

This incredible phenomenon in the lives of the Marsili family got the attention of scientists and medical experts. It was later on revealed that this extraordinary ability to not feel pain is due to a mutation in the ZFHX2 gene.

Dr. James Cox from the University of College London explains that the nervous system of the family works in a way that is totally different from a normal person. He was quoted as saying:

If we find out the reason for that absence of pain, then perhaps this will help us create a new generation of pain medication.

Scientists eventually named the mutation after the family, calling it the Marsili Syndrome. Apart from not having the capability to feel pain, this syndrome results in an individual being less sensitive to anything cold and/or hot.

The genetic mutation has also affected the younger generation of the family.

While they may have unique abilities, Letizia says that they do not really differ from other families.

Now that we know about our syndrome, we are more careful and attentive to ourselves. Even if it were possible, I would not want to get rid of this feature. Eventually, one day, research will lead to a discovery that will push science forward and help humanity.

What do you think about the rare condition of the Marsili family? Do you know someone who also has rare and unique mutations? Be sure to let us know in the comments below!


Scientists Find Large Ice Cliffs on Mars, Possible Source of Water for Future Missions

The discovery is greatly beneficial for future missions to the Red Planet.




A group of scientists recently announced their discovery of huge deposits of water ice near the surface of Mars. This discovery could forever change all future explorations of the Red Planet.

The findings were published in the journal Science. The research was led by Colin Dundas from the US Geological Survey in Arizona.

The discovery was made using the HiRISE (High Resolution Imaging Science Experiment) instrument on the Mars Reconnaissance Orbiter.

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The World’s Largest Retirement Community is Perfect for Testing Self-Driving Taxis

An American startup company has chosen the area to pilot its services.




Autonomous vehicle technology has yet to be perfected, but one company is looking to take one step ahead of the others as it tests its services in the ideal area: The Villages retirement community in Florida. The sprawling community stretches out to 40 square miles and features 750 miles of road, three separate downtowns, plus a population of 125,000 senior citizens.

The American car startup Voyage chose The Villages to test its door-to-door self-driving taxi service. With this, the residents can call for cars using an app. The cars will then operate at Level 4 autonomy (meaning full autonomy for all safety-critical driving functions) but still include a safety driver. The company has also partnered with CARMERA, a street-level intelligence provider for autonomous vehicles. CARMERA will map out The Villages’ roadways and feed the cars real-time mapping updates.

The Villages was picked because of its large dynamic space.

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Scientists Discover Huge Sheets of Ice Buried Beneath the Surface of Mars

This discovery is a big ‘game-changer,’ according to experts.

Mark Andrew



A major discovery has just been made by scientists and many are labeling it as a huge ‘game-changer’. According to a new study published in the Science journal, Mars may have a source of accessible drinkable water.

As can be seen in the images taken by NASA's Mars Reconnaissance Orbiter (which has been orbiting the red planet since 2006), scientists have discovered thick ice sheets under the Martain surface.

This marks the first time exposed ice has been spotted on the planet’s surface.

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